Reaction Details Report a problem with these data
Target
Similar to alpha-tubulin isoform 1
Ligand
BDBM50037450
Substrate
n/a
Meas. Tech.
ChEMBL_211318 (CHEMBL818978)
IC50
490±n/a nM
Citation
 Zhang, SX; Bastow, KF; Tachibana, Y; Kuo, SC; Hamel, E; Mauger, A; Narayanan, VL; Lee, KH Antitumor agents. 196. Substituted 2-thienyl-1,8-naphthyridin-4-ones: their synthesis, cytotoxicity, and inhibition of tubulin polymerization. J Med Chem 42:4081-7 (1999) [PubMed]  Article 
Target
Name:
Similar to alpha-tubulin isoform 1
Synonyms:
Similar to alpha-tubulin isoform 1
Type:
PROTEIN
Mol. Mass.:
10383.05
Organism:
Bos taurus
Description:
ChEMBL_104716
Residue:
99
Sequence:
CVSASPSTLARLVSRSAMPAGSSTAWNTAFSPMARCQVTKTIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRSSSTLSSSSQAKKMP
  
Inhibitor
Name:
BDBM50037450
Synonyms:
2-(3-Methoxy-phenyl)-6-pyrrolidin-1-yl-1H-quinolin-4-one | 2-(3-Methoxy-phenyl)-6-pyrrolidin-1-yl-1H-quinolin-4-one (PQ-7) | 2-(3-methoxyphenyl)-6-pyrrolinylquinolin-4-one | CHEMBL15778 | NSC-664171
Type:
Small organic molecule
Emp. Form.:
C20H20N2O2
Mol. Mass.:
320.385
SMILES:
COc1cccc(c1)-c1cc(O)c2cc(ccc2n1)N1CCCC1
Structure:
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