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Target
5-hydroxytryptamine receptor 1D
Ligand
BDBM50473501
Substrate
n/a
Meas. Tech.
ChEMBL_1743 (CHEMBL616948)
IC50
65±n/a nM
Citation
 Jandu, KS; Barrett, V; Brockwell, M; Cambridge, D; Farrant, DR; Foster, C; Giles, H; Glen, RC; Hill, AP; Hobbs, H; Honey, A; Martin, GR; Salmon, J; Smith, D; Woollard, P; Selwood, DL Discovery of 4-[3-(trans-3-dimethylaminocyclobutyl)-1H-indol-5-ylmethyl]-(4S)-oxazolidin-2-one (4991W93), a 5HT(1B/1D) receptor partial agonist and a potent inhibitor of electrically induced plasma extravasation. J Med Chem 44:681-93 (2001) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1D
Synonyms:
5-HT-1D | 5-HT-1D-alpha | 5-HT1D | 5-hydroxytryptamine receptor 1D (5-HT1D) | 5HT1D_HUMAN | HTR1D | HTR1DA | HTRL | Serotonin (5-HT) receptor | Serotonin Receptor 1D
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
41920.63
Organism:
Homo sapiens (Human)
Description:
Receptor binding assays were performed using human clone stably expressed in CHO cells.
Residue:
377
Sequence:
MSPLNQSAEGLPQEASNRSLNATETSEAWDPRTLQALKISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAATMIAIVWAISICISIPPLFWRQAKAQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLIILYGRIYRAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLNSSLHEGHSHSAGSPLFFNHVKIKLADSALERKRISAARERKATKILGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIVPFRKAS
  
Inhibitor
Name:
BDBM50473501
Synonyms:
CHEMBL2368253
Type:
Small organic molecule
Emp. Form.:
C20H22N2O
Mol. Mass.:
306.4015
SMILES:
CN(C)[C@H]1C[C@@H](C1)c1c[nH]c2ccc(Oc3ccccc3)cc12 |wU:3.2,wD:5.7,(11.39,-13.98,;12.4,-12.84,;13.91,-13.14,;11.92,-11.37,;10.55,-10.69,;11.23,-9.32,;12.61,-9.99,;10.76,-7.85,;11.65,-6.6,;10.74,-5.35,;9.27,-5.84,;7.94,-5.07,;6.61,-5.86,;6.61,-7.4,;5.27,-8.17,;5.27,-9.71,;6.6,-10.46,;6.61,-12,;5.27,-12.79,;3.93,-12,;3.94,-10.46,;7.94,-8.17,;9.29,-7.38,)|
Structure:
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