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Target
5-hydroxytryptamine receptor 1A
Ligand
BDBM50473593
Substrate
n/a
Meas. Tech.
ChEMBL_1023 (CHEMBL616225)
Ki
2.1±n/a nM
Citation
 Peglion, JL; Goument, B; Despaux, N; Charlot, V; Giraud, H; Nisole, C; Newman-Tancredi, A; Dekeyne, A; Bertrand, M; Genissel, P; Millan, MJ Improvement in the selectivity and metabolic stability of the serotonin 5-HT(1A) ligand, S 15535: a series of cis- and trans-2-(arylcycloalkylamine) 1-indanols. J Med Chem 45:165-76 (2002) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-HT-1A | 5-HT1A | 5-hydroxytryptamine receptor 1A (5-HT-1A) | 5HT1A_HUMAN | ADRB2RL1 | ADRBRL1 | Dopamine D2 receptor and serotonin 1a receptor | G-21 | HTR1A | Serotonin receptor 1A
Type:
n/a
Mol. Mass.:
46122.49
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
422
Sequence:
MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRQ
  
Inhibitor
Name:
BDBM50473593
Synonyms:
CHEMBL50903
Type:
Small organic molecule
Emp. Form.:
C21H22F2N2O3
Mol. Mass.:
388.4078
SMILES:
O[C@H]1[C@@H](Cc2cc(F)c(F)cc12)N1CCN(CC1)c1cccc2OCCOc12
Structure:
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