Reaction Details Report a problem with these data
Target
Tubulin beta chain
Ligand
BDBM50475541
Substrate
n/a
Meas. Tech.
ChEMBL_326923 (CHEMBL854312)
IC50
18000±n/a nM
Citation
 Li, PK; Xiao, Z; Hu, Z; Pandit, B; Sun, Y; Sackett, DL; Werbovetz, K; Lewis, A; Johnsamuel, J Conformationally restricted analogs of Combretastatin A-4 derived from SU5416. Bioorg Med Chem Lett 15:5382-5 (2005) [PubMed]  Article 
Target
Name:
Tubulin beta chain
Synonyms:
Beta-tubulin | TBB_PIG | Tubulin beta chain
Type:
PROTEIN
Mol. Mass.:
49840.26
Organism:
Sus scrofa
Description:
ChEMBL_105107
Residue:
445
Sequence:
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEAAGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADEQGEFEEEGEEDEA
  
Inhibitor
Name:
BDBM50475541
Synonyms:
CHEMBL196754
Type:
Small organic molecule
Emp. Form.:
C16H13NO3
Mol. Mass.:
267.2793
SMILES:
COc1ccc2\C(=C/c3ccc(O)cc3)C(=O)Nc2c1
Structure:
Search PDB for entries with ligand similarity: