Reaction Details Report a problem with these data
Target
Cathepsin K
Ligand
BDBM50213272
Substrate
n/a
Meas. Tech.
ChEMBL_425100 (CHEMBL913665)
IC50
42.2±n/a nM
Citation
 Zeng, GZ; Tan, NH; Hao, XJ; Mu, QZ; Li, RT Natural inhibitors targeting osteoclast-mediated bone resorption. Bioorg Med Chem Lett 16:6178-80 (2006) [PubMed]  Article 
Target
Name:
Cathepsin K
Synonyms:
CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X
Type:
Enzyme
Mol. Mass.:
36975.68
Organism:
Homo sapiens (Human)
Description:
P43235
Residue:
329
Sequence:
MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM
  
Inhibitor
Name:
BDBM50213272
Synonyms:
CHEBI:6426 | Leupeptin
Type:
Small organic molecule
Emp. Form.:
C20H38N6O4
Mol. Mass.:
426.5535
SMILES:
CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C=O |r|
Structure:
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