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Target
Proteinase-activated receptor 2
Ligand
BDBM50477085
Substrate
n/a
Meas. Tech.
ChEMBL_449273 (CHEMBL899535)
EC50
1300±n/a nM
Citation
 Barry, GD; Suen, JY; Low, HB; Pfeiffer, B; Flanagan, B; Halili, M; Le, GT; Fairlie, DP A refined agonist pharmacophore for protease activated receptor 2. Bioorg Med Chem Lett 17:5552-7 (2007) [PubMed]  Article 
Target
Name:
Proteinase-activated receptor 2
Synonyms:
F2RL1 | GPR11 | PAR2 | PAR2_HUMAN
Type:
PROTEIN
Mol. Mass.:
44152.54
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1497756
Residue:
397
Sequence:
MRSPSAAWLLGAAILLAASLSCSGTIQGTNRSSKGRSLIGKVDGTSHVTGKGVTVETVFSVDEFSASVLTGKLTTVFLPIVYTIVFVVGLPSNGMALWVFLFRTKKKHPAVIYMANLALADLLSVIWFPLKIAYHIHGNNWIYGEALCNVLIGFFYGNMYCSILFMTCLSVQRYWVIVNPMGHSRKKANIAIGISLAIWLLILLVTIPLYVVKQTIFIPALNITTCHDVLPEQLLVGDMFNYFLSLAIGVFLFPAFLTASAYVLMIRMLRSSAMDENSEKKRKRAIKLIVTVLAMYLICFTPSNLLLVVHYFLIKSQGQSHVYALYIVALCLSTLNSCIDPFVYYFVSHDFRDHAKNALLCRSVRTVKQMQVSLTSKKHSRKSSSYSSSSTTVKTSY
  
Inhibitor
Name:
BDBM50477085
Synonyms:
CHEMBL237114
Type:
Small organic molecule
Emp. Form.:
C43H76N11O11P
Mol. Mass.:
954.1044
SMILES:
CCOP(=O)(Cc1ccc(C[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CO)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O)cc1)OCC
Structure:
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