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Target
Reverse transcriptase
Ligand
BDBM50476711
Substrate
n/a
Meas. Tech.
ChEMBL_465754 (CHEMBL948998)
IC50
5200±n/a nM
Citation
 Cullen, MD; Sarkar, T; Hamel, E; Hartman, TL; Watson, KM; Buckheit, RW; Pannecouque, C; De Clercq, E; Cushman, M Inhibition of tubulin polymerization by select alkenyldiarylmethanes. Bioorg Med Chem Lett 18:469-73 (2008) [PubMed]  Article 
Target
Name:
Reverse transcriptase
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
29598.37
Organism:
Human immunodeficiency virus 1
Description:
Q9WKE8
Residue:
254
Sequence:
PISPITVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKIEKIGPENPYNTPVFAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIEQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVN
  
Inhibitor
Name:
BDBM50476711
Synonyms:
CHEMBL387804
Type:
Small organic molecule
Emp. Form.:
C27H29N3O5S
Mol. Mass.:
507.601
SMILES:
COc1noc2c(C)cc(cc12)C(=C/CCCc1nnc(C)o1)\c1cc(C)c(OC)c(c1)C(=O)SC
Structure:
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