Reaction Details Report a problem with these data
Target
Growth hormone secretagogue receptor type 1
Ligand
BDBM50478232
Substrate
n/a
Meas. Tech.
ChEMBL_474273 (CHEMBL935078)
EC50
0.398107±n/a nM
Citation
 Witherington, J; Abberley, L; Briggs, MA; Collis, K; Dean, DK; Gaiba, A; King, NP; Kraus, H; Shuker, N; Steadman, JG; Takle, AK; Sanger, G; Wadsworth, G; Butler, S; McKay, F; Muir, A; Winborn, K; Heightman, TD Potent achiral agonists of the growth hormone secretagogue (ghrelin) receptor. Part 2: Lead optimisation. Bioorg Med Chem Lett 18:2203-5 (2008) [PubMed]  Article 
Target
Name:
Growth hormone secretagogue receptor type 1
Synonyms:
GH-releasing peptide receptor | GHRP | GHS-R | GHSR | GHSR_HUMAN | Ghrelin Receptor (Growth Hormone Secretagogue Receptor Type 1) | Ghrelin receptor | Ghrelin receptor 1a (GHS-R1a)
Type:
Receptor
Mol. Mass.:
41334.57
Organism:
Homo sapiens (Human)
Description:
Receptor binding studies use plasma membranes from LLC PK-1 cells transiently transfected with hGHSR1a.
Residue:
366
Sequence:
MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT
  
Inhibitor
Name:
BDBM50478232
Synonyms:
CHEMBL260819
Type:
Small organic molecule
Emp. Form.:
C26H30FN3O4S
Mol. Mass.:
499.598
SMILES:
COc1ccc(F)c(c1)-c1ccc(cc1)S(=O)(=O)Nc1cc(ccc1OC)N1C[C@H](C)N[C@H](C)C1
Structure:
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