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Target
Reverse transcriptase
Ligand
BDBM50480752
Substrate
n/a
Meas. Tech.
ChEMBL_581398 (CHEMBL1053305)
IC50
3360±n/a nM
Citation
 Monforte, AM; Logoteta, P; Ferro, S; De Luca, L; Iraci, N; Maga, G; Clercq, ED; Pannecouque, C; Chimirri, A Design, synthesis, and structure-activity relationships of 1,3-dihydrobenzimidazol-2-one analogues as anti-HIV agents. Bioorg Med Chem 17:5962-7 (2009) [PubMed]  Article 
Target
Name:
Reverse transcriptase
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
29598.37
Organism:
Human immunodeficiency virus 1
Description:
Q9WKE8
Residue:
254
Sequence:
PISPITVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKIEKIGPENPYNTPVFAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIEQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVN
  
Inhibitor
Name:
BDBM50480752
Synonyms:
CHEMBL560475
Type:
Small organic molecule
Emp. Form.:
C16H16Cl2N2O3S
Mol. Mass.:
387.281
SMILES:
Cc1cc(C)cc(c1)S(=O)(=O)Nc1cc(Cl)ccc1NC(=O)CCl
Structure:
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