Reaction Details Report a problem with these data
Target
Genome polyprotein
Ligand
BDBM50482597
Substrate
n/a
Meas. Tech.
ChEMBL_651836 (CHEMBL1227201)
Ki
6400±n/a nM
Citation
Ortqvist, P; Gising, J; Ehrenberg, AE; Vema, A; Borg, A; Karlén, A; Larhed, M; Danielson, UH; Sandström, A Discovery of achiral inhibitors of the hepatitis C virus NS3 protease based on 2(1H)-pyrazinones. Bioorg Med Chem 18:6512-25 (2010) [PubMed] Article
More Info.:
Target
Name:
Genome polyprotein
Synonyms:
Protease NS3/Non-structural protein 4A (NS3/NS4A) | Protease NS3/Non-structural protein 4A (NS3/NS4A) (D168V)
Type:
Enzyme
Mol. Mass.:
19121.30
Organism:
Hepatitis C virus genotype 1b (isolate Con1) (HCV)
Description:
Q91RS4
Residue:
181
Sequence:
APITAYAQQTRGLLGCIITSLTGRDKNQVEGEVQIVSTAAQTFLATCINGVCWTVYHGAGTRTIASPKGPVIQMYTNVDQDLVGWPAPQGARSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPISYLKGSSGGPLLCPAGHAVGLFRAAVCTRGVAKAVDFIPVENLETTMRS