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Target
DNA topoisomerase type IB small subunit
Ligand
BDBM50239186
Substrate
n/a
Meas. Tech.
ChEMBL_730545 (CHEMBL1697632)
Kd
380000±n/a nM
Citation
Roy, A; BoseDasgupta, S; Ganguly, A; Jaisankar, P; Majumder, HK Topoisomerase I gene mutations at F270 in the large subunit and N184 in the small subunit contribute to the resistance mechanism of the unicellular parasite Leishmania donovani towards 3,3'-diindolylmethane. Antimicrob Agents Chemother 53:2589-98 (2009) [PubMed] Article
More Info.:
Target
Name:
DNA topoisomerase type IB small subunit
Synonyms:
DNA topoisomerase IB small subunit
Type:
Protein
Mol. Mass.:
28120.90
Organism:
Leishmania donovani
Description:
E9B7X3
Residue:
262
Sequence:
MQPVQSPPVAPPSVPVAAPKKTPIDISALKLKMSPSVRATLAAAGVLGQCPRPIEAADEDALLKLKPMKTMVPSVKKVVAPVATTAPPPKVRRVESSSSSSSDSSSSSSDDDSSSDDSSGSDSSSYSSDDRSSSSAESVVSGEATLFHIAQSQGLVNKEVLTQEEEEVPTLVPPRPPVVRSFPNDIGKALERYRERLNREESIIRIKDDNKAVSLGTSKINYIDPRIICSWAKAQDVPINKIFSATIQKKFPWAMNAENFDF