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Target
DNA topoisomerase I
Ligand
BDBM50239186
Substrate
n/a
Meas. Tech.
ChEMBL_730543 (CHEMBL1697630)
Kd
760000±n/a nM
Citation
 Roy, A; BoseDasgupta, S; Ganguly, A; Jaisankar, P; Majumder, HK Topoisomerase I gene mutations at F270 in the large subunit and N184 in the small subunit contribute to the resistance mechanism of the unicellular parasite Leishmania donovani towards 3,3'-diindolylmethane. Antimicrob Agents Chemother 53:2589-98 (2009) [PubMed]  Article 
Target
Name:
DNA topoisomerase I
Synonyms:
DNA topoisomerase IB large subunit
Type:
Protein
Mol. Mass.:
73610.41
Organism:
Leishmania donovani
Description:
E9BRC0
Residue:
635
Sequence:
MKVENSKMGVKREQSHSNEDEEINEEDLNWWEQENLRIAMKGERRWETLAHNGVLFPPEYEPHGIPIFYDGREFKMTPEEEEVATMFAVMKEHDYYRMEVFRRNFFESWREILDKRQHPIRRLELCDFEPIYQWHLVQREKKLSRTKEEKKAIKEKQDAEAEPYRYCVWDGRREQVANFRVEPPGLFRGRGKHPLMGKLKVRVQPEDITINIGETAEVPVPPAGHKWAAVQHDHTVTWLAMWRDSVAGNMKYVMLAPSSSVKGQSDMVKFEKARKLKDKVDDIRASYMEDFKSNDLHVAQRAVAMYFIDRLALRVGNEKGEDEADTVGCCSLRVEHIQLMPDNIVRFDFLGKDSIRYQNDVAVLPEVYALLQRFTRRKSPGTDIFDQLNPTQLNDHLKSFMDGLSAKVFRTYNASITLDRWFKEKPVDPKWSTADKLAYFNKANTEVAILCNHQKSVSKNFKLQMMQLTTKSEYTRKTIELLEKAEVTAKKKSVEEAAKEFLEEQDRMQREWLESYGTEEQKKEFEEIVAKRAAPRVRSEKKKSTSGAKKAESASGKKRAAKKKKSAKKGGKVLSKKAASKSSKKAPKKLKEEDEDDVPLVSVAAKTKKTAGVKRQRANKVVSDDDDVPLAALRV
  
Inhibitor
Name:
BDBM50239186
Synonyms:
1,1-Bis(3''-Indolyl)Methane | 3,3''-Diindolylmethane | 3,3-Diindolylmethane | Arundine | CHEBI:50182 | Diindolylmethane
Type:
Small organic molecule
Emp. Form.:
C17H14N2
Mol. Mass.:
246.3065
SMILES:
C(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12
Structure:
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