Reaction Details Report a problem with these data
Target
Solute carrier family 22 member 5
Ligand
BDBM50350470
Substrate
n/a
Meas. Tech.
ChEMBL_836620 (CHEMBL2077361)
IC50
1700000±n/a nM
Citation
 Ganapathy, ME; Huang, W; Rajan, DP; Carter, AL; Sugawara, M; Iseki, K; Leibach, FH; Ganapathy, V beta-lactam antibiotics as substrates for OCTN2, an organic cation/carnitine transporter. J Biol Chem 275:1699-707 (2000) [PubMed]  Article 
Target
Name:
Solute carrier family 22 member 5
Synonyms:
High-affinity sodium-dependent carnitine cotransporter | OCTN2 | OCTN2_HUMAN | Organic cation/carnitine transporter 2 | SLC22A5 | Solute carrier family 22 member 5
Type:
PROTEIN
Mol. Mass.:
62756.52
Organism:
Homo sapiens
Description:
ChEMBL_104634
Residue:
557
Sequence:
MRDYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPDAANLSSAWRNHTVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIFSTLGVCIFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEVIIRKAAKANGIVVPSTIFDPSELQDLSSKKQQSHNILDLLRTWNIRMVTIMSIMLWMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTIDQMLRVKGMKHRKTPSHTRMLKDGQERPTILKSTAF
  
Inhibitor
Name:
BDBM50350470
Synonyms:
CEFEPIME | Maxipime
Type:
Small organic molecule
Emp. Form.:
C19H24N6O5S2
Mol. Mass.:
480.561
SMILES:
CO\N=C(/C(=O)N[C@H]1[C@H]2SCC(C[N+]3(C)CCCC3)=C(N2C1=O)C([O-])=O)c1csc(N)n1 |r,c:19|
Structure:
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