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Target
Bcl-2 homologous antagonist/killer
Ligand
BDBM50485616
Substrate
n/a
Meas. Tech.
ChEMBL_840681 (CHEMBL2090423)
IC50
>50000±n/a nM
Citation
 Yusuff, N; Doré, M; Joud, C; Visser, M; Springer, C; Xie, X; Herlihy, K; Porter, D; Touré, BB Lipophilic Isosteres of a ?-? Stacking Interaction: New Inhibitors of the Bcl-2-Bak Protein-Protein Interaction. ACS Med Chem Lett 3:579-83 (2012) [PubMed]  Article 
Target
Name:
Bcl-2 homologous antagonist/killer
Synonyms:
Apoptosis regulator BAK | BAK | BAK1 | BAK_HUMAN | BCL2L7 | Bcl-2 homologous antagonist/killer | Bcl-2-like protein 7 | Bcl2-L-7 | CDN1
Type:
PROTEIN
Mol. Mass.:
23406.37
Organism:
Homo sapiens
Description:
ChEMBL_117067
Residue:
211
Sequence:
MASGQGPGPPRQECGEPALPSASEEQVAQDTEEVFRSYVFYRHQQEQEAEGVAAPADPEMVTLPLQPSSTMGQVGRQLAIIGDDINRRYDSEFQTMLQHLQPTAENAYEYFTKIATSLFESGINWGRVVALLGFGYRLALHVYQHGLTGFLGQVTRFVVDFMLHHCIARWIAQRGGWVAALNLGNGPILNVLVVLGVVLLGQFVVRRFFKS
  
Inhibitor
Name:
BDBM50485616
Synonyms:
CHEMBL2089286
Type:
Small organic molecule
Emp. Form.:
C34H38ClN3O4S
Mol. Mass.:
620.201
SMILES:
CC1(C)C2CC[C@@]1(CS(=O)(=O)NC(=O)c1ccc(cc1)N1CCN(Cc3ccccc3-c3ccc(Cl)cc3)CC1)C(=O)C2 |r|
Structure:
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