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Target
Bcl-2 homologous antagonist/killer
Ligand
BDBM50485619
Substrate
n/a
Meas. Tech.
ChEMBL_840681 (CHEMBL2090423)
IC50
>50000±n/a nM
Citation
 Yusuff, N; Doré, M; Joud, C; Visser, M; Springer, C; Xie, X; Herlihy, K; Porter, D; Touré, BB Lipophilic Isosteres of a ?-? Stacking Interaction: New Inhibitors of the Bcl-2-Bak Protein-Protein Interaction. ACS Med Chem Lett 3:579-83 (2012) [PubMed]  Article 
Target
Name:
Bcl-2 homologous antagonist/killer
Synonyms:
Apoptosis regulator BAK | BAK | BAK1 | BAK_HUMAN | BCL2L7 | Bcl-2 homologous antagonist/killer | Bcl-2-like protein 7 | Bcl2-L-7 | CDN1
Type:
PROTEIN
Mol. Mass.:
23406.37
Organism:
Homo sapiens
Description:
ChEMBL_117067
Residue:
211
Sequence:
MASGQGPGPPRQECGEPALPSASEEQVAQDTEEVFRSYVFYRHQQEQEAEGVAAPADPEMVTLPLQPSSTMGQVGRQLAIIGDDINRRYDSEFQTMLQHLQPTAENAYEYFTKIATSLFESGINWGRVVALLGFGYRLALHVYQHGLTGFLGQVTRFVVDFMLHHCIARWIAQRGGWVAALNLGNGPILNVLVVLGVVLLGQFVVRRFFKS
  
Inhibitor
Name:
BDBM50485619
Synonyms:
CHEMBL2089291
Type:
Small organic molecule
Emp. Form.:
C34H39ClN4O3S
Mol. Mass.:
619.216
SMILES:
Clc1ccc(cc1)-c1ccccc1CN1CCN(CC1)c1ccc(cc1)C(=O)NS(=O)(=O)NC12CC3CC(CC(C3)C1)C2 |TLB:36:37:34.35.40:41,THB:36:35:41:42.37.38,38:37:34:40.39.41,38:39:34:42.36.37|
Structure:
Search PDB for entries with ligand similarity: