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Target
Bcl-2 homologous antagonist/killer
Ligand
BDBM50485620
Substrate
n/a
Meas. Tech.
ChEMBL_840681 (CHEMBL2090423)
IC50
>50000±n/a nM
Citation
 Yusuff, N; Doré, M; Joud, C; Visser, M; Springer, C; Xie, X; Herlihy, K; Porter, D; Touré, BB Lipophilic Isosteres of a ?-? Stacking Interaction: New Inhibitors of the Bcl-2-Bak Protein-Protein Interaction. ACS Med Chem Lett 3:579-83 (2012) [PubMed]  Article 
Target
Name:
Bcl-2 homologous antagonist/killer
Synonyms:
Apoptosis regulator BAK | BAK | BAK1 | BAK_HUMAN | BCL2L7 | Bcl-2 homologous antagonist/killer | Bcl-2-like protein 7 | Bcl2-L-7 | CDN1
Type:
PROTEIN
Mol. Mass.:
23406.37
Organism:
Homo sapiens
Description:
ChEMBL_117067
Residue:
211
Sequence:
MASGQGPGPPRQECGEPALPSASEEQVAQDTEEVFRSYVFYRHQQEQEAEGVAAPADPEMVTLPLQPSSTMGQVGRQLAIIGDDINRRYDSEFQTMLQHLQPTAENAYEYFTKIATSLFESGINWGRVVALLGFGYRLALHVYQHGLTGFLGQVTRFVVDFMLHHCIARWIAQRGGWVAALNLGNGPILNVLVVLGVVLLGQFVVRRFFKS
  
Inhibitor
Name:
BDBM50485620
Synonyms:
CHEMBL2089293
Type:
Small organic molecule
Emp. Form.:
C36H42ClN3O3S
Mol. Mass.:
632.255
SMILES:
Clc1ccc(cc1)-c1ccccc1CN1CCN(CC1)c1ccc(cc1)C(=O)NS(=O)(=O)CC12CC3CC(C1)CCC(C3)C2 |TLB:36:35:43:38.37.40.39,36:37:34.35.42:43,THB:40:41:34:38.36.37,39:37:34:42.41.43|
Structure:
Search PDB for entries with ligand similarity: