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Target
Bcl-2 homologous antagonist/killer
Ligand
BDBM50485625
Substrate
n/a
Meas. Tech.
ChEMBL_840681 (CHEMBL2090423)
IC50
>50000±n/a nM
Citation
 Yusuff, N; Doré, M; Joud, C; Visser, M; Springer, C; Xie, X; Herlihy, K; Porter, D; Touré, BB Lipophilic Isosteres of a ?-? Stacking Interaction: New Inhibitors of the Bcl-2-Bak Protein-Protein Interaction. ACS Med Chem Lett 3:579-83 (2012) [PubMed]  Article 
Target
Name:
Bcl-2 homologous antagonist/killer
Synonyms:
Apoptosis regulator BAK | BAK | BAK1 | BAK_HUMAN | BCL2L7 | Bcl-2 homologous antagonist/killer | Bcl-2-like protein 7 | Bcl2-L-7 | CDN1
Type:
PROTEIN
Mol. Mass.:
23406.37
Organism:
Homo sapiens
Description:
ChEMBL_117067
Residue:
211
Sequence:
MASGQGPGPPRQECGEPALPSASEEQVAQDTEEVFRSYVFYRHQQEQEAEGVAAPADPEMVTLPLQPSSTMGQVGRQLAIIGDDINRRYDSEFQTMLQHLQPTAENAYEYFTKIATSLFESGINWGRVVALLGFGYRLALHVYQHGLTGFLGQVTRFVVDFMLHHCIARWIAQRGGWVAALNLGNGPILNVLVVLGVVLLGQFVVRRFFKS
  
Inhibitor
Name:
BDBM50485625
Synonyms:
CHEMBL2089288
Type:
Small organic molecule
Emp. Form.:
C36H44ClN3O3S
Mol. Mass.:
634.271
SMILES:
C[C@]12C[C@](C)([C@H](CS(=O)(=O)NC(=O)c3ccc(cc3)N3CCN(Cc4ccccc4-c4ccc(Cl)cc4)CC3)CC1)C2(C)C |r|
Structure:
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