Reaction Details Report a problem with these data
Target
Bcl-2 homologous antagonist/killer
Ligand
BDBM50485627
Substrate
n/a
Meas. Tech.
ChEMBL_840681 (CHEMBL2090423)
IC50
>50000±n/a nM
Citation
 Yusuff, N; Doré, M; Joud, C; Visser, M; Springer, C; Xie, X; Herlihy, K; Porter, D; Touré, BB Lipophilic Isosteres of a ?-? Stacking Interaction: New Inhibitors of the Bcl-2-Bak Protein-Protein Interaction. ACS Med Chem Lett 3:579-83 (2012) [PubMed]  Article 
Target
Name:
Bcl-2 homologous antagonist/killer
Synonyms:
Apoptosis regulator BAK | BAK | BAK1 | BAK_HUMAN | BCL2L7 | Bcl-2 homologous antagonist/killer | Bcl-2-like protein 7 | Bcl2-L-7 | CDN1
Type:
PROTEIN
Mol. Mass.:
23406.37
Organism:
Homo sapiens
Description:
ChEMBL_117067
Residue:
211
Sequence:
MASGQGPGPPRQECGEPALPSASEEQVAQDTEEVFRSYVFYRHQQEQEAEGVAAPADPEMVTLPLQPSSTMGQVGRQLAIIGDDINRRYDSEFQTMLQHLQPTAENAYEYFTKIATSLFESGINWGRVVALLGFGYRLALHVYQHGLTGFLGQVTRFVVDFMLHHCIARWIAQRGGWVAALNLGNGPILNVLVVLGVVLLGQFVVRRFFKS
  
Inhibitor
Name:
BDBM50485627
Synonyms:
CHEMBL2089283
Type:
Small organic molecule
Emp. Form.:
C28H32ClN3O3S
Mol. Mass.:
526.09
SMILES:
CC(C)(C)S(=O)(=O)NC(=O)c1ccc(cc1)N1CCN(Cc2ccccc2-c2ccc(Cl)cc2)CC1
Structure:
Search PDB for entries with ligand similarity: