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Target
Protoporphyrinogen oxidase
Ligand
BDBM50359925
Substrate
n/a
Meas. Tech.
ChEMBL_893548 (CHEMBL3049525)
Ki
324±n/a nM
Citation
 Jiang, LL; Tan, Y; Zhu, XL; Wang, ZF; Zuo, Y; Chen, Q; Xi, Z; Yang, GF Design, synthesis, and 3D-QSAR analysis of novel 1,3,4-oxadiazol-2(3H)-ones as protoporphyrinogen oxidase inhibitors. J Agric Food Chem 58:2643-51 (2010) [PubMed]  Article 
Target
Name:
Protoporphyrinogen oxidase
Synonyms:
PPO | PPOX | PPOX_HUMAN
Type:
PROTEIN
Mol. Mass.:
50774.78
Organism:
Homo sapiens (Human)
Description:
ChEMBL_791250
Residue:
477
Sequence:
MGRTVVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRGPNGAIFELGPRGIRPAGALGARTLLLVSELGLDSEVLPVRGDHPAAQNRFLYVGGALHALPTGLRGLLRPSPPFSKPLFWAGLRELTKPRGKEPDETVHSFAQRRLGPEVASLAMDSLCRGVFAGNSRELSIRSCFPSLFQAEQTHRSILLGLLLGAGRTPQPDSALIRQALAERWSQWSLRGGLEMLPQALETHLTSRGVSVLRGQPVCGLSLQAEGRWKVSLRDSSLEADHVISAIPASVLSELLPAEAAPLARALSAITAVSVAVVNLQYQGAHLPVQGFGHLVPSSEDPGVLGIVYDSVAFPEQDGSPPGLRVTVMLGGSWLQTLEASGCVLSQELFQQRAQEAAATQLGLKEMPSHCLVHLHKNCIPQYTLGHWQKLESARQFLTAHRLPLTLAGASYEGVAVNDCIESGRQAAVSVLGTEPNS
  
Inhibitor
Name:
BDBM50359925
Synonyms:
CHEMBL1926960
Type:
Small organic molecule
Emp. Form.:
C18H20FN3O4S2
Mol. Mass.:
425.498
SMILES:
CCOC(=O)CCSc1nc2cc(c(F)cc2s1)-n1nc(oc1=O)C(C)(C)C
Structure:
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