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Target
Protoporphyrinogen oxidase
Ligand
BDBM50487192
Substrate
n/a
Meas. Tech.
ChEMBL_908776 (CHEMBL3066844)
Ki
302±n/a nM
Citation
 Zhang, L; Tan, Y; Wang, NX; Wu, QY; Xi, Z; Yang, GF Design, syntheses and 3D-QSAR studies of novel N-phenyl pyrrolidin-2-ones and N-phenyl-1H-pyrrol-2-ones as protoporphyrinogen oxidase inhibitors. Bioorg Med Chem 18:7948-56 (2010) [PubMed]  Article 
Target
Name:
Protoporphyrinogen oxidase
Synonyms:
PPO | PPOX | PPOX_HUMAN
Type:
PROTEIN
Mol. Mass.:
50774.78
Organism:
Homo sapiens (Human)
Description:
ChEMBL_791250
Residue:
477
Sequence:
MGRTVVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRGPNGAIFELGPRGIRPAGALGARTLLLVSELGLDSEVLPVRGDHPAAQNRFLYVGGALHALPTGLRGLLRPSPPFSKPLFWAGLRELTKPRGKEPDETVHSFAQRRLGPEVASLAMDSLCRGVFAGNSRELSIRSCFPSLFQAEQTHRSILLGLLLGAGRTPQPDSALIRQALAERWSQWSLRGGLEMLPQALETHLTSRGVSVLRGQPVCGLSLQAEGRWKVSLRDSSLEADHVISAIPASVLSELLPAEAAPLARALSAITAVSVAVVNLQYQGAHLPVQGFGHLVPSSEDPGVLGIVYDSVAFPEQDGSPPGLRVTVMLGGSWLQTLEASGCVLSQELFQQRAQEAAATQLGLKEMPSHCLVHLHKNCIPQYTLGHWQKLESARQFLTAHRLPLTLAGASYEGVAVNDCIESGRQAAVSVLGTEPNS
  
Inhibitor
Name:
BDBM50487192
Synonyms:
CHEMBL2252321
Type:
Small organic molecule
Emp. Form.:
C17H19Cl2NO2
Mol. Mass.:
340.244
SMILES:
CCCOc1cc(N2CC3=C(CCCC3)C2=O)c(Cl)cc1Cl |t:9|
Structure:
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