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Target
Protoporphyrinogen oxidase
Ligand
BDBM50487215
Substrate
n/a
Meas. Tech.
ChEMBL_908776 (CHEMBL3066844)
Ki
780±n/a nM
Citation
 Zhang, L; Tan, Y; Wang, NX; Wu, QY; Xi, Z; Yang, GF Design, syntheses and 3D-QSAR studies of novel N-phenyl pyrrolidin-2-ones and N-phenyl-1H-pyrrol-2-ones as protoporphyrinogen oxidase inhibitors. Bioorg Med Chem 18:7948-56 (2010) [PubMed]  Article 
Target
Name:
Protoporphyrinogen oxidase
Synonyms:
PPO | PPOX | PPOX_HUMAN
Type:
PROTEIN
Mol. Mass.:
50774.78
Organism:
Homo sapiens (Human)
Description:
ChEMBL_791250
Residue:
477
Sequence:
MGRTVVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRGPNGAIFELGPRGIRPAGALGARTLLLVSELGLDSEVLPVRGDHPAAQNRFLYVGGALHALPTGLRGLLRPSPPFSKPLFWAGLRELTKPRGKEPDETVHSFAQRRLGPEVASLAMDSLCRGVFAGNSRELSIRSCFPSLFQAEQTHRSILLGLLLGAGRTPQPDSALIRQALAERWSQWSLRGGLEMLPQALETHLTSRGVSVLRGQPVCGLSLQAEGRWKVSLRDSSLEADHVISAIPASVLSELLPAEAAPLARALSAITAVSVAVVNLQYQGAHLPVQGFGHLVPSSEDPGVLGIVYDSVAFPEQDGSPPGLRVTVMLGGSWLQTLEASGCVLSQELFQQRAQEAAATQLGLKEMPSHCLVHLHKNCIPQYTLGHWQKLESARQFLTAHRLPLTLAGASYEGVAVNDCIESGRQAAVSVLGTEPNS
  
Inhibitor
Name:
BDBM50487215
Synonyms:
CHEMBL2252325
Type:
Small organic molecule
Emp. Form.:
C21H18ClF2NO3
Mol. Mass.:
405.822
SMILES:
OC1N(C(=O)C2=C1CCCC2)c1cc(OCc2cccc(F)c2)c(Cl)cc1F |c:5|
Structure:
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