Reaction Details Report a problem with these data
Target
Delta(14)-sterol reductase
Ligand
BDBM50487254
Substrate
n/a
Meas. Tech.
ChEMBL_909060 (CHEMBL3049784)
IC50
40000±n/a nM
Citation
 Taton, M; Benveniste, P; Rahier, A Microsomal delta 8,14-sterol delta 14-reductase in higher plants. Characterization and inhibition by analogues of a presumptive carbocationic intermediate of the reduction reaction. Eur J Biochem 185:605-14 (1989) [PubMed]  Article 
Target
Name:
Delta(14)-sterol reductase
Synonyms:
100281352 | Delta(14)-sterol reductase
Type:
PROTEIN
Mol. Mass.:
41580.42
Organism:
Zea mays
Description:
ChEMBL_106555
Residue:
370
Sequence:
MEAAAAVLPTLVPSGSAVVVLLAYLGYLAAAGAILPGKLVDGALLPDSSRLHYRCNGLLSLLLLLGLSAFGVYMGWMSPTVVADMGLELLSVTFIFSVIVSFALYIAGIKSGHKSSSLRPHVSGSFMQDWWFGVQLNPHFMEVDLKFFFVRAGMMAWLFINLSLFAKSYFAGSANLSVILYQFFCAWYIIDYFVHEEFMTSTWDIIAERLGFMLVFGDLVFIPFTFTIQGWWLLKNKVELSLLSGLANLCIFLIGYLVFRGANKQKHVFKKDPKAPIWGKPPKVVGGKLLASGYWGIARHCNYLGDLLLALSFSLPCGVSSVVPYFYPTYLLILLVLRERRDEARCSQKYREIWAEYCKLVPWRILPYVY
  
Inhibitor
Name:
BDBM50487254
Synonyms:
CHEMBL3215942
Type:
Small organic molecule
Emp. Form.:
C22H32Cl6N2
Mol. Mass.:
537.221
SMILES:
Cl.Cl.Cl.Cl.Clc1ccccc1CNC[C@H]1CC[C@H](CNCc2ccccc2Cl)CC1 |r,wU:17.14,wD:14.10,(3.9,.01,;11.6,.01,;9.03,.01,;6.47,.01,;-16.01,2.8,;-16.01,1.57,;-17.34,.8,;-17.34,-.74,;-16.01,-1.51,;-14.67,-.74,;-14.67,.8,;-13.34,1.57,;-12,.79,;-10.67,1.56,;-9.33,.79,;-9.34,-.75,;-8.01,-1.53,;-6.67,-.76,;-5.34,-1.53,;-4,-.77,;-2.67,-1.54,;-1.33,-.77,;-1.33,.77,;,1.54,;1.33,.77,;1.33,-.77,;,-1.54,;,-2.77,;-6.67,.78,;-8,1.55,)|
Structure:
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