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Target
Glycogen synthase kinase-3 beta
Ligand
BDBM50537531
Substrate
n/a
Meas. Tech.
ChEMBL_1969953 (CHEMBL4602771)
IC50
94±n/a nM
Citation
 Xu, M; Wang, SL; Zhu, L; Wu, PY; Dai, WB; Rakesh, KP Structure-activity relationship (SAR) studies of synthetic glycogen synthase kinase-3? inhibitors: A critical review. Eur J Med Chem 164:448-470 (2019) [PubMed]  Article 
Target
Name:
Glycogen synthase kinase-3 beta
Synonyms:
GSK-3 beta | GSK-3, beta | GSK3B | GSK3B_HUMAN | Glycogen synthase kinase 3 beta (GSK3B) | Glycogen synthase kinase 3-beta (GSK3B) | Glycogen synthase kinase-3 beta (GSK-3B) | Glycogen synthase kinase-3 beta (GSK3 Beta) | Glycogen synthase kinase-3 beta (GSK3B) | Glycogen synthase kinase-3B (GSK-3B) | Glycogen synthase kinase-3beta (GSK3B) | Serine/threonine-protein kinase GSK3B
Type:
Enzyme
Mol. Mass.:
46756.38
Organism:
Homo sapiens (Human)
Description:
P49841
Residue:
420
Sequence:
MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
  
Inhibitor
Name:
BDBM50537531
Synonyms:
CHEMBL4641105
Type:
Small organic molecule
Emp. Form.:
C22H23N5OS
Mol. Mass.:
405.516
SMILES:
CCc1ccc(cc1)-n1cc(CSC2=NC(CC(=O)N2C)c2ccccc2)nn1 |t:14|
Structure:
Search PDB for entries with ligand similarity: