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Target
Dihydrofolate reductase
Ligand
BDBM50031868
Substrate
n/a
Meas. Tech.
ChEMBL_52846 (CHEMBL665050)
IC50
2600±n/a nM
Citation
 Rosowsky, A; Forsch, RA; Queener, SF 2,4-Diaminopyrido[3,2-d]pyrimidine inhibitors of dihydrofolate reductase from Pneumocystis carinii and Toxoplasma gondii. J Med Chem 38:2615-20 (1995) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
DYR_PNECA | Dihydrofolate Reductase (DHFR) | Dihydrofolate reductase | Dihydrofolate reductase; P. carinii vs rat | Tetrahydrofolate dehydrogenase
Type:
Enzyme
Mol. Mass.:
23891.29
Organism:
Pneumocystis carinii
Description:
n/a
Residue:
206
Sequence:
MNQQKSLTLIVALTTSYGIGRSNSLPWKLKKEISYFKRVTSFVPTFDSFESMNVVLMGRKTWESIPLQFRPLKGRINVVITRNESLDLGNGIHSAKSLDHALELLYRTYGSESSVQINRIFVIGGAQLYKAAMDHPKLDRIMATIIYKDIHCDVFFPLKFRDKEWSSVWKKEKHSDLESWVGTKVPHGKINEDGFDYEFEMWTRDL
  
Inhibitor
Name:
BDBM50031868
Synonyms:
6-((3,4,5-trimethoxyphenylamino)methyl)pyrido[3,2-d]pyrimidine-2,4-diamine | 6-[(3,4,5-Trimethoxy-phenylamino)-methyl]-pyrido[3,2-d]pyrimidine-2,4-diamine | CHEMBL55179
Type:
Small organic molecule
Emp. Form.:
C17H20N6O3
Mol. Mass.:
356.3791
SMILES:
COc1cc(NCc2ccc3nc(N)nc(N)c3n2)cc(OC)c1OC
Structure:
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