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Target
Protoporphyrinogen oxidase, chloroplastic
Ligand
BDBM50488402
Substrate
n/a
Meas. Tech.
ChEMBL_924308 (CHEMBL3081412)
Ki
580±n/a nM
Citation
 Zuo, Y; Yang, SG; Luo, YP; Tan, Y; Hao, GF; Wu, QY; Xi, Z; Yang, GF Design and synthesis of 1-(benzothiazol-5-yl)-1H-1,2,4-triazol-5-ones as protoporphyrinogen oxidase inhibitors. Bioorg Med Chem 21:3245-55 (2013) [PubMed]  Article 
Target
Name:
Protoporphyrinogen oxidase, chloroplastic
Synonyms:
1.3.3.4 | PPO | PPO I | PPOC_TOBAC | PPX I | PPXI | Protoporphyrinogen IX oxidase isozyme I | Protoporphyrinogen oxidase, chloroplastic
Type:
PROTEIN
Mol. Mass.:
59244.44
Organism:
Nicotiana tabacum
Description:
ChEMBL_106599
Residue:
548
Sequence:
MTTTPIANHPNIFTHQSSSSPLAFLNRTSFIPFSSISKRNSVNCNGWRTRCSVAKDYTVPSSAVDGGPAAELDCVIVGAGISGLCIAQVMSANYPNLMVTEARDRAGGNITTVERDGYLWEEGPNSFQPSDPMLTMAVDCGLKDDLVLGDPNAPRFVLWKGKLRPVPSKLTDLAFFDLMSIPGKLRAGFGAIGLRPSPPGHEESVEQFVRRNLGGEVFERLIEPFCSGVYAGDPSKLSMKAAFGKVWKLEETGGSIIGGTFKAIKERSSTPKAPRDPRLPKPKGQTVGSFRKGLRMLPDAISARLGSKLKLSWKLSSITKSEKGGYHLTYETPEGVVSLQSRSIVMTVPSYVASNILRPLSVAAADALSNFYYPPVGAVTITYPQEAIRDERLVDGELKGFGQLHPRTQGVETLGTIYSSSLFPNRAPKGRVLLLNYIGGAKNPEILSKTESQLVEVVDRDLRKMLIKPKAQDPLVVGVRVWPQAIPQFLVGHLDTLSTAKAAMNDNGLEGLFLGGNYVSGVALGRCVEGAYEVASEVTGFLSRYAYK
  
Inhibitor
Name:
BDBM50488402
Synonyms:
CHEMBL2286467
Type:
Small organic molecule
Emp. Form.:
C14H11F3N4O3S2
Mol. Mass.:
404.387
SMILES:
CCOC(=O)Sc1nc2cc(c(F)cc2s1)-n1nc(C)n(C(F)F)c1=O
Structure:
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