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Target
Dihydrofolate reductase
Ligand
BDBM50033553
Substrate
n/a
Meas. Tech.
ChEMBL_55140 (CHEMBL668783)
IC50
38±n/a nM
Citation
 Gangjee, A; Zaveri, N; Kothare, M; Queener, SF Nonclassical 2,4-diamino-6-(aminomethyl)-5,6,7,8-tetrahydroquinazoline antifolates: synthesis and biological activities. J Med Chem 38:3660-8 (1995) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
DYR_RAT | Dhfr | Dihydrofolate reductase (DHFR) | Dihydrofolate reductase; P. carinii vs rat | Tetrahydrofolate dehydrogenase
Type:
Enzyme
Mol. Mass.:
21638.84
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
187
Sequence:
MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKFEVYEKKD
  
Inhibitor
Name:
BDBM50033553
Synonyms:
6-{[Methyl-(3,4,5-trimethoxy-phenyl)-amino]-methyl}-5,6,7,8-tetrahydro-quinazoline-2,4-diamine | CHEMBL123122
Type:
Small organic molecule
Emp. Form.:
C19H27N5O3
Mol. Mass.:
373.4494
SMILES:
COc1cc(cc(OC)c1OC)N(C)CC1CCc2nc(N)nc(N)c2C1
Structure:
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