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Target
Mu-type opioid receptor
Ligand
BDBM50033651
Substrate
n/a
Meas. Tech.
ChEBML_136067
IC50
1.5±n/a nM
Citation
 Sebastian, A; Bidlack, JM; Jiang, Q; Deecher, D; Teitler, M; Glick, SD; Archer, S 14 beta-[(p-nitrocinnamoyl)amino]morphinones, 14 beta-[(p-nitrocinnamoyl)amino]-7,8-dihydromorphinones, and their codeinone analogues: synthesis and receptor activity. J Med Chem 36:3154-60 (1993) [PubMed]  Article 
Target
Name:
Mu-type opioid receptor
Synonyms:
MOR-1 | Mu opioid receptor | OPIATE Mu | OPRM1 | OPRM_BOVIN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
45038.37
Organism:
CALF
Description:
OPIATE Mu 2 0 CALF::P79350
Residue:
401
Sequence:
MDSGAVPTNASNCTDPFTHPSSCSPAPSPSSWVNFSHLEGNLSDPCGPNRTELGGSDRLCPSAGSPSMITAIIIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDLRTPRNAKIINICNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPILIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETTPLP
  
Inhibitor
Name:
BDBM50033651
Synonyms:
1N-[10-hydroxy-4-methyl-14-oxo-(13R,17S)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10,15-tetraen-17-yl]-4-(4-nitrophenyl)-(Z)-2-butenamide | CHEMBL110238
Type:
Small organic molecule
Emp. Form.:
C26H23N3O6
Mol. Mass.:
473.4773
SMILES:
CN1CCC23[C@H]4Oc5c2c(CC1[C@]3(NC(=O)C=Cc1ccc(cc1)[N+]([O-])=O)C=CC4=O)ccc5O |w:17.20,c:31,TLB:13:12:8.9.10:1.3.2,THB:0:1:12:8.9.10,7:8:12:1.3.2|
Structure:
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