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Target
Beta-lactamase
Ligand
BDBM50033699
Substrate
n/a
Meas. Tech.
ChEMBL_40542 (CHEMBL652172)
IC50
>20000±n/a nM
Citation
 Buynak, JD; Wu, K; Bachmann, B; Khasnis, D; Hua, L; Nguyen, HK; Carver, CL Synthesis and biological activity of 7-alkylidenecephems. J Med Chem 38:1022-34 (1995) [PubMed]  Article 
Target
Name:
Beta-lactamase
Synonyms:
AMPC_ENTCL | ampC
Type:
PROTEIN
Mol. Mass.:
41306.67
Organism:
Enterobacter cloacae
Description:
ChEMBL_40258
Residue:
381
Sequence:
MMRKSLCCALLLGISCSALATPVSEKQLAEVVANTITPLMKAQSVPGMAVAVIYQGKPHYYTFGKADIAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDAVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMPYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMAPENVADASLKQGIALAQSRYWRIGSMYQGLGWEMLNWPVEANTVVEGSDSKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQIGIVMLANTSYPNPARVEAAYHILEALQ
  
Inhibitor
Name:
BDBM50033699
Synonyms:
CHEMBL8511 | Sodium; (R)-3-acetoxymethyl-5,5,8-trioxo-7-[1-phenyl-meth-(E)-ylidene]-5lambda*6*-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate
Type:
Small organic molecule
Emp. Form.:
C17H14NO7S
Mol. Mass.:
376.361
SMILES:
CC(=O)OCC1=C(N2[C@@H](\C(=C\c3ccccc3)C2=O)S(=O)(=O)C1)C([O-])=O |t:5|
Structure:
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