Reaction Details Report a problem with these data
Target
Protein-S-isoprenylcysteine O-methyltransferase
Ligand
BDBM50034277
Substrate
n/a
Meas. Tech.
ChEMBL_158698 (CHEMBL763229)
Ki
8100±n/a nM
Citation
 Marciano, D; Ben-Baruch, G; Marom, M; Egozi, Y; Haklai, R; Kloog, Y Farnesyl derivatives of rigid carboxylic acids-inhibitors of ras-dependent cell growth. J Med Chem 38:1267-72 (1995) [PubMed]  Article 
Target
Name:
Protein-S-isoprenylcysteine O-methyltransferase
Synonyms:
ICMT_RAT | Icmt | Isoprenylcysteine carboxyl methyltransferase
Type:
PROTEIN
Mol. Mass.:
26663.61
Organism:
Rattus norvegicus
Description:
ChEMBL_158698
Residue:
232
Sequence:
ALLLLLYRPPHYQIAIRACFLGFVFGCGVLLSFSQSSWNHFGWYVCSLSLFHYSEYLVTTVNNPKSLSLDSFLLNHSLEYTVAALSSWIEFTLENIFWPELKQITWLSAAGLLMVIFGECLRKVAMFTAGSNFNHVVQSEKSDTHTLVTSGVYAWCRHPSYVGWFYWSIGTQVMLCNPICGVVYALTVWRFFRDRTEEEEISLIHFFGEEYLDYKKRVPTGLPFIKGVKVGL
  
Inhibitor
Name:
BDBM50034277
Synonyms:
CHEMBL23289 | Thioacetic acid S-((2E,6E)-3,7,11-trimethyl-dodeca-2,6,10-trienyl) ester
Type:
Small organic molecule
Emp. Form.:
C17H28OS
Mol. Mass.:
280.469
SMILES:
[#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#16]-[#6](-[#6])=O
Structure:
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