Reaction Details Report a problem with these data
Target
Protein-S-isoprenylcysteine O-methyltransferase
Ligand
BDBM50034278
Substrate
n/a
Meas. Tech.
ChEMBL_158698 (CHEMBL763229)
Ki
2800±n/a nM
Citation
Marciano, D; Ben-Baruch, G; Marom, M; Egozi, Y; Haklai, R; Kloog, Y Farnesyl derivatives of rigid carboxylic acids-inhibitors of ras-dependent cell growth. J Med Chem 38:1267-72 (1995) [PubMed] Article
More Info.:
Target
Name:
Protein-S-isoprenylcysteine O-methyltransferase
Synonyms:
ICMT_RAT | Icmt | Isoprenylcysteine carboxyl methyltransferase
Type:
PROTEIN
Mol. Mass.:
26663.61
Organism:
Rattus norvegicus
Description:
ChEMBL_158698
Residue:
232
Sequence:
ALLLLLYRPPHYQIAIRACFLGFVFGCGVLLSFSQSSWNHFGWYVCSLSLFHYSEYLVTTVNNPKSLSLDSFLLNHSLEYTVAALSSWIEFTLENIFWPELKQITWLSAAGLLMVIFGECLRKVAMFTAGSNFNHVVQSEKSDTHTLVTSGVYAWCRHPSYVGWFYWSIGTQVMLCNPICGVVYALTVWRFFRDRTEEEEISLIHFFGEEYLDYKKRVPTGLPFIKGVKVGL
Inhibitor
Name:
BDBM50034278
Synonyms:
2-((2E,6E)-3,7,11-Trimethyl-dodeca-2,6,10-trienylsulfanyl)-benzoic acid | CHEMBL23293 | Farnesylthiosalicyclic acid | Farnesylthiosalicylic acid | S-trans,trans-farnesylthiosalicylic acid
Type:
Small organic molecule
Emp. Form.:
C22H30O2S
Mol. Mass.:
358.537
SMILES:
[#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#16]-c1ccccc1-[#6](-[#8])=O