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Target
Neutrophil elastase
Ligand
BDBM50034672
Substrate
n/a
Meas. Tech.
ChEMBL_63998 (CHEMBL673107)
Ki
20.5±n/a nM
Citation
 Desai, RC; Court, JC; Ferguson, E; Gordon, RJ; Hlasta, DJ; Dunlap, RP; Franke, CA Phosphonates and phosphinates: novel leaving groups for benzisothiazolone inhibitors of human leukocyte elastase. J Med Chem 38:1571-4 (1995) [PubMed]  Article 
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM50034672
Synonyms:
CHEMBL290748 | Phosphoric acid dibenzyl ester 1,1,3-trioxo-1,3-dihydro-1lambda*6*-benzo[d]isothiazol-2-ylmethyl ester
Type:
Small organic molecule
Emp. Form.:
C22H20NO7PS
Mol. Mass.:
473.435
SMILES:
O=C1N(COP(=O)(OCc2ccccc2)OCc2ccccc2)S(=O)(=O)c2ccccc12
Structure:
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