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Target
Peroxisome proliferator-activated receptor gamma
Ligand
BDBM50171897
Substrate
n/a
Meas. Tech.
ChEMBL_955713 (CHEMBL2379023)
EC50
2692±n/a nM
Citation
 Carrieri, A; Giudici, M; Parente, M; De Rosas, M; Piemontese, L; Fracchiolla, G; Laghezza, A; Tortorella, P; Carbonara, G; Lavecchia, A; Gilardi, F; Crestani, M; Loiodice, F Molecular determinants for nuclear receptors selectivity: chemometric analysis, dockings and site-directed mutagenesis of dual peroxisome proliferator-activated receptors ?/? agonists. Eur J Med Chem 63:321-32 (2013) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor gamma
Synonyms:
NR1C3 | Nuclear receptor subfamily 1 group C member 3 | PPAR-gamma | PPARG | PPARG_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor gamma (PPAR gamma) | Peroxisome proliferator-activated receptor gamma (PPARG) | Peroxisome proliferator-activated receptor gamma (PPARĪ³) | Peroxisome proliferator-activated receptor gamma/Nuclear receptor corepressor 2 | peroxisome proliferator-activated receptor gamma isoform 2
Type:
Nuclear Receptor
Mol. Mass.:
57613.46
Organism:
Homo sapiens (Human)
Description:
P37231
Residue:
505
Sequence:
MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY
  
Inhibitor
Name:
BDBM50171897
Synonyms:
(2S)-2-(4-chlorophenoxy)-3-phenylpropanoic acid | (S)-2-(4-Chloro-phenoxy)-3-phenyl-propionic acid | (S)-2-(4-chlorophenoxy)-3-phenylpropanoic acid | CHEMBL364748
Type:
Small organic molecule
Emp. Form.:
C15H13ClO3
Mol. Mass.:
276.715
SMILES:
OC(=O)[C@H](Cc1ccccc1)Oc1ccc(Cl)cc1 |r|
Structure:
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