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Target
Muscarinic acetylcholine receptor M2
Ligand
BDBM50036164
Substrate
n/a
Meas. Tech.
ChEMBL_139350 (CHEMBL752398)
Ki
9200±n/a nM
Citation
 Nilsson, BM; Sundquist, S; Johansson, G; Nordvall, G; Glas, G; Nilvebrant, L; Hacksell, U 3-Heteroaryl-substituted quinuclidin-3-ol and quinuclidin-2-ene derivatives as muscarinic antagonists. Synthesis and structure-activity relationships. J Med Chem 38:473-87 (1995) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M2
Synonyms:
ACM2_HUMAN | CHRM2 | Cholinergic, muscarinic M2 | Muscarinic acetylcholine receptor M2 and M4 | Muscarinic acetylcholine receptor M2 and M5 | RecName: Full=Muscarinic acetylcholine receptor M2
Type:
GPCR
Mol. Mass.:
51730.61
Organism:
Homo sapiens (Human)
Description:
P08172
Residue:
466
Sequence:
MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
  
Inhibitor
Name:
BDBM50036164
Synonyms:
3-Benzooxazol-2-yl-1-aza-bicyclo[2.2.2]octan-3-ol | CHEMBL145533
Type:
Small organic molecule
Emp. Form.:
C14H16N2O2
Mol. Mass.:
244.289
SMILES:
OC1(CN2CCC1CC2)c1nc2ccccc2o1 |(2.9,-13.97,;2.91,-15.51,;2.91,-17.05,;1.57,-17.71,;.24,-17.05,;.24,-15.51,;1.57,-14.74,;1.88,-15.98,;.94,-16.45,;4.38,-15.11,;4.87,-13.64,;6.42,-13.64,;7.44,-12.52,;8.93,-12.82,;9.41,-14.3,;8.38,-15.44,;6.88,-15.11,;5.64,-16.03,)|
Structure:
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