Reaction Details Report a problem with these data
Target
Renin
Ligand
BDBM50036976
Substrate
n/a
Meas. Tech.
ChEMBL_192898 (CHEMBL795111)
IC50
33±n/a nM
Citation
Boyd, SA; Fung, AK; Baker, WR; Mantei, RA; Stein, HH; Cohen, J; Barlow, JL; Klinghofer, V; Wessale, JL; Verburg, KM Nonpeptide renin inhibitors with good intraduodenal bioavailability and efficacy in dog. J Med Chem 37:2991-3007 (1994) [PubMed] Article
More Info.:
Target
Name:
Renin
Synonyms:
Angiotensinogenase | REN | RENI_HUMAN
Type:
Enzyme
Mol. Mass.:
45058.99
Organism:
Human
Description:
n/a
Residue:
406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
Inhibitor
Name:
BDBM50036976
Synonyms:
(2S,4S,5S)-5-{(S)-2-[(S)-1-Benzyl-2-(4-methoxymethoxy-piperidin-1-yl)-2-oxo-ethylamino]-hexanoylamino}-6-cyclohexyl-4-hydroxy-2-isopropyl-hexanoic acid (2-pyridin-2-yl-ethyl)-amide | CHEMBL101075
Type:
Small organic molecule
Emp. Form.:
C44H69N5O6
Mol. Mass.:
764.0486
SMILES:
CCCC[C@H](N[C@@H](Cc1ccccc1)C(=O)N1CCC(CC1)OCOC)C(=O)N[C@@H](CC1CCCCC1)[C@@H](O)C[C@@H](C(C)C)C(=O)NCCc1ccccn1