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Target
Melanin-concentrating hormone receptor 1
Ligand
BDBM50492360
Substrate
n/a
Meas. Tech.
ChEMBL_971498 (CHEMBL2406560)
EC50
30±n/a nM
Citation
 Qian, Y; Conde-Knape, K; Erickson, SD; Falcioni, F; Gillespie, P; Hakimi, I; Mennona, F; Ren, Y; Salari, H; So, SS; Tilley, JW Potent MCH-1 receptor antagonists from cis-1,4-diaminocyclohexane-derived indane analogs. Bioorg Med Chem Lett 23:4216-20 (2013) [PubMed]  Article 
Target
Name:
Melanin-concentrating hormone receptor 1
Synonyms:
G-protein coupled receptor 24 | GPR24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCHR | MCHR-1 | MCHR1 | MCHR1_HUMAN | Melanin Concentrating Hormone 1 | Melanin-Concentrating Hormone Receptor 1 (MCH1R) | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 1 (MCH-1) | Melanin-concentrating hormone receptor 1 (MCH1) | Melanin-concentrating hormone receptor 1 (MCHR-1) | Melanin-concentrating hormone receptor 1 (MCHR1) | SLC-1 | SLC1 | Somatostatin receptor-like protein
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
45976.27
Organism:
Homo sapiens (Human)
Description:
Membranes from CHO-K1 cells stably expressing human MCH1R were used in assays.
Residue:
422
Sequence:
MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
  
Inhibitor
Name:
BDBM50492360
Synonyms:
CHEMBL2403856
Type:
Small organic molecule
Emp. Form.:
C26H30N4
Mol. Mass.:
398.5432
SMILES:
Cc1nc2cc(C)ccc2n1[C@@H]1CC[C@@H](CC1)NC[C@H]1Cc2ccc(cc2C1)C#N |r,wU:11.12,14.19,19.21,(37.22,-25.78,;36.05,-26.77,;34.55,-26.4,;33.74,-27.72,;32.21,-27.99,;31.7,-29.44,;30.18,-29.72,;32.69,-30.62,;34.21,-30.35,;34.74,-28.9,;36.16,-28.32,;37.49,-29.1,;37.43,-30.66,;38.75,-31.47,;40.1,-30.76,;40.16,-29.19,;38.84,-28.37,;41.43,-31.54,;42.77,-30.79,;42.79,-29.25,;41.54,-28.33,;42.03,-26.87,;41.28,-25.54,;42.06,-24.22,;43.6,-24.23,;44.35,-25.57,;43.57,-26.89,;44.04,-28.35,;44.37,-22.91,;45.15,-21.58,)|
Structure:
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