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Target
Melanin-concentrating hormone receptor 1
Ligand
BDBM50492356
Substrate
n/a
Meas. Tech.
ChEMBL_971498 (CHEMBL2406560)
EC50
20±n/a nM
Citation
 Qian, Y; Conde-Knape, K; Erickson, SD; Falcioni, F; Gillespie, P; Hakimi, I; Mennona, F; Ren, Y; Salari, H; So, SS; Tilley, JW Potent MCH-1 receptor antagonists from cis-1,4-diaminocyclohexane-derived indane analogs. Bioorg Med Chem Lett 23:4216-20 (2013) [PubMed]  Article 
Target
Name:
Melanin-concentrating hormone receptor 1
Synonyms:
G-protein coupled receptor 24 | GPR24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCHR | MCHR-1 | MCHR1 | MCHR1_HUMAN | Melanin Concentrating Hormone 1 | Melanin-Concentrating Hormone Receptor 1 (MCH1R) | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 1 (MCH-1) | Melanin-concentrating hormone receptor 1 (MCH1) | Melanin-concentrating hormone receptor 1 (MCHR-1) | Melanin-concentrating hormone receptor 1 (MCHR1) | SLC-1 | SLC1 | Somatostatin receptor-like protein
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
45976.27
Organism:
Homo sapiens (Human)
Description:
Membranes from CHO-K1 cells stably expressing human MCH1R were used in assays.
Residue:
422
Sequence:
MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
  
Inhibitor
Name:
BDBM50492356
Synonyms:
CHEMBL2403854
Type:
Small organic molecule
Emp. Form.:
C25H30ClN3
Mol. Mass.:
407.979
SMILES:
Cc1nc2cc(C)ccc2n1[C@@H]1CC[C@@H](CC1)NCC1Cc2ccc(Cl)cc2C1 |r,wU:11.12,14.19,(6.58,-24.86,;5.4,-25.85,;3.9,-25.49,;3.09,-26.8,;1.57,-27.07,;1.05,-28.53,;-.46,-28.8,;2.04,-29.7,;3.56,-29.43,;4.09,-27.98,;5.51,-27.4,;6.85,-28.18,;6.79,-29.74,;8.1,-30.55,;9.45,-29.84,;9.51,-28.27,;8.19,-27.45,;10.79,-30.62,;12.13,-29.87,;12.14,-28.33,;10.9,-27.41,;11.39,-25.95,;10.64,-24.62,;11.41,-23.3,;12.95,-23.31,;13.73,-21.99,;13.7,-24.65,;12.92,-25.97,;13.39,-27.43,)|
Structure:
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