Reaction Details Report a problem with these data
Target
Melanin-concentrating hormone receptor 1
Ligand
BDBM50492347
Substrate
n/a
Meas. Tech.
ChEMBL_971498 (CHEMBL2406560)
EC50
70±n/a nM
Citation
 Qian, Y; Conde-Knape, K; Erickson, SD; Falcioni, F; Gillespie, P; Hakimi, I; Mennona, F; Ren, Y; Salari, H; So, SS; Tilley, JW Potent MCH-1 receptor antagonists from cis-1,4-diaminocyclohexane-derived indane analogs. Bioorg Med Chem Lett 23:4216-20 (2013) [PubMed]  Article 
Target
Name:
Melanin-concentrating hormone receptor 1
Synonyms:
G-protein coupled receptor 24 | GPR24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCHR | MCHR-1 | MCHR1 | MCHR1_HUMAN | Melanin Concentrating Hormone 1 | Melanin-Concentrating Hormone Receptor 1 (MCH1R) | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 1 (MCH-1) | Melanin-concentrating hormone receptor 1 (MCH1) | Melanin-concentrating hormone receptor 1 (MCHR-1) | Melanin-concentrating hormone receptor 1 (MCHR1) | SLC-1 | SLC1 | Somatostatin receptor-like protein
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
45976.27
Organism:
Homo sapiens (Human)
Description:
Membranes from CHO-K1 cells stably expressing human MCH1R were used in assays.
Residue:
422
Sequence:
MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
  
Inhibitor
Name:
BDBM50492347
Synonyms:
CHEMBL2403852
Type:
Small organic molecule
Emp. Form.:
C25H30BrN3
Mol. Mass.:
452.43
SMILES:
Cc1nc2cc(C)ccc2n1[C@@H]1CC[C@@H](CC1)NC[C@H]1Cc2ccc(Br)cc2C1 |r,wU:19.21,wD:11.12,14.19,(10.24,-8.49,;9.76,-9.96,;8.29,-10.43,;8.29,-11.97,;7.15,-13,;7.47,-14.51,;6.33,-15.54,;8.93,-14.99,;10.08,-13.96,;9.76,-12.45,;10.66,-11.2,;12.2,-11.2,;12.97,-9.87,;14.51,-9.87,;15.28,-11.2,;14.51,-12.54,;12.97,-12.54,;16.82,-11.2,;17.59,-9.87,;19.13,-9.87,;20.04,-8.62,;21.5,-9.1,;22.84,-8.33,;24.17,-9.1,;24.17,-10.64,;25.51,-11.41,;22.84,-11.41,;21.5,-10.64,;20.04,-11.12,)|
Structure:
Search PDB for entries with ligand similarity: