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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50492382
Substrate
n/a
Meas. Tech.
ChEMBL_972028 (CHEMBL2405979)
IC50
2.0±n/a nM
Citation
 Wrobleski, ST; Lin, S; Dhar, TG; Dyckman, AJ; Li, T; Pitt, S; Zhang, R; Fan, Y; Doweyko, AM; Tokarski, JS; Kish, KF; Kiefer, SE; Sack, JS; Newitt, JA; Witmer, MR; McKinnon, M; Barrish, JC; Dodd, JH; Schieven, GL; Leftheris, K The identification of novel p38? isoform selective kinase inhibitors having an unprecedented p38? binding mode. Bioorg Med Chem Lett 23:4120-6 (2013) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50492382
Synonyms:
CHEMBL2401981
Type:
Small organic molecule
Emp. Form.:
C22H19ClN2O2S
Mol. Mass.:
410.916
SMILES:
Cc1ccc(cc1NC(=O)c1ccc(s1)-c1ccc(Cl)cc1)C(=O)NC1CC1
Structure:
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