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Target
Kappa-type opioid receptor
Ligand
BDBM50039100
Substrate
n/a
Meas. Tech.
ChEMBL_145681 (CHEMBL754277)
IC50
3.8±n/a nM
Citation
 Naylor, A; Judd, DB; Scopes, DI; Hayes, AG; Birch, PJ 4-[(Alkylamino)methyl]furo[3,2-c]pyridines: a new series of selective kappa-receptor agonists. J Med Chem 37:2138-44 (1994) [PubMed]  Article 
Target
Name:
Kappa-type opioid receptor
Synonyms:
K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42648.76
Organism:
Homo sapiens (Human)
Description:
P41145
Residue:
380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
  
Inhibitor
Name:
BDBM50039100
Synonyms:
2-(3,4-Dichloro-phenyl)-1-[5-hydroxy-1-(3-hydroxy-pyrrolidin-1-ylmethyl)-3,4-dihydro-1H-isoquinolin-2-yl]-ethanone | CHEMBL68354
Type:
Small organic molecule
Emp. Form.:
C22H24Cl2N2O3
Mol. Mass.:
435.344
SMILES:
OC1CCN(CC2N(CCc3c(O)cccc23)C(=O)Cc2ccc(Cl)c(Cl)c2)C1
Structure:
Search PDB for entries with ligand similarity: