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Target
Purine nucleoside phosphorylase
Ligand
BDBM50039561
Substrate
n/a
Meas. Tech.
ChEMBL_162034 (CHEMBL766674)
IC50
10±n/a nM
Citation
 Niwas, S; Chand, P; Pathak, VP; Montgomery, JA Structure-based design of inhibitors of purine nucleoside phosphorylase. 5. 9-Deazahypoxanthines. J Med Chem 37:2477-80 (1994) [PubMed]  Article 
Target
Name:
Purine nucleoside phosphorylase
Synonyms:
Inosine phosphorylase | Np | PNPH_RAT | Pnp | Purine nucleoside phosphorylase | Purine-nucleoside phosphorylase | nucleoside phosphorylase
Type:
PROTEIN
Mol. Mass.:
32303.61
Organism:
Rattus norvegicus
Description:
ChEMBL_162034
Residue:
289
Sequence:
MENEFTYEDYQRTAEWLRSHTKHRPQVAVICGSGLGGLTAKLTQPQAFDYNEIPNFPQSTVQGHAGRLVFGFLNGRSCVMMQGRFHMYEGYSLSKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFCGQNPLRGPNDERFGVRFPAMSDAYDRDMRQKAFNAWKQMGEQRELQEGTYIMSAGPTFETVAESCLLRMLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVVMDYNNLEKASHQEVLEAGKAAAQKLEQFVSILMESIPPRERAN
  
Inhibitor
Name:
BDBM50039561
Synonyms:
3-(3-Chloro-phenyl)-3-(4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)-propionitrile | CHEMBL315570
Type:
Small organic molecule
Emp. Form.:
C15H11ClN4O
Mol. Mass.:
298.727
SMILES:
Clc1cccc(c1)C(CC#N)c1c[nH]c2c1nc[nH]c2=O
Structure:
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