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Target
Purine nucleoside phosphorylase
Ligand
BDBM50039542
Substrate
n/a
Meas. Tech.
ChEMBL_162034 (CHEMBL766674)
IC50
25±n/a nM
Citation
 Niwas, S; Chand, P; Pathak, VP; Montgomery, JA Structure-based design of inhibitors of purine nucleoside phosphorylase. 5. 9-Deazahypoxanthines. J Med Chem 37:2477-80 (1994) [PubMed]  Article 
Target
Name:
Purine nucleoside phosphorylase
Synonyms:
Inosine phosphorylase | Np | PNPH_RAT | Pnp | Purine nucleoside phosphorylase | Purine-nucleoside phosphorylase | nucleoside phosphorylase
Type:
PROTEIN
Mol. Mass.:
32303.61
Organism:
Rattus norvegicus
Description:
ChEMBL_162034
Residue:
289
Sequence:
MENEFTYEDYQRTAEWLRSHTKHRPQVAVICGSGLGGLTAKLTQPQAFDYNEIPNFPQSTVQGHAGRLVFGFLNGRSCVMMQGRFHMYEGYSLSKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFCGQNPLRGPNDERFGVRFPAMSDAYDRDMRQKAFNAWKQMGEQRELQEGTYIMSAGPTFETVAESCLLRMLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVVMDYNNLEKASHQEVLEAGKAAAQKLEQFVSILMESIPPRERAN
  
Inhibitor
Name:
BDBM50039542
Synonyms:
2-Amino-7-pyridin-3-ylmethyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one | 2-amino-7-(pyridin-3-ylmethyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one | 2-amino-7-(pyridin-3-ylmethyl)-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one | CHEMBL311300
Type:
Small organic molecule
Emp. Form.:
C12H11N5O
Mol. Mass.:
241.2486
SMILES:
Nc1nc2c(Cc3cccnc3)c[nH]c2c(=O)[nH]1
Structure:
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