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Target
Acyl-CoA:cholesterol acyltransferase
Ligand
BDBM50040854
Substrate
n/a
Meas. Tech.
ChEMBL_28192 (CHEMBL637685)
IC50
27±n/a nM
Citation
 Kumazawa, T; Yanase, M; Harakawa, H; Obase, H; Shirakura, S; Ohishi, E; Oda, S; Kubo, K; Yamada, K Inhibitors of acyl-CoA:cholesterol acyltransferase. 1. Synthesis and hypocholesterolemic activity of dibenz[b,e]oxepin-11-carboxanilides. J Med Chem 37:804-10 (1994) [PubMed]  Article 
Target
Name:
Acyl-CoA:cholesterol acyltransferase
Synonyms:
ACAT
Type:
n/a
Mol. Mass.:
35405.31
Organism:
Oryctolagus cuniculus
Description:
n/a
Residue:
305
Sequence:
PLFLKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSILKEMKNNHRAKDLRAPPEQGKIFVARRSLLDELFEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFNLLSYAFGKLPTVVWTWWTMFLSTLSIPYFLFQHWANGYSKSSHPLMYSLFHGLLFMVFQLGILGFGPTYIVLAYTLPPASRFIVILEQIRLIMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYFLFAPTLIYRDSYPRTPTVRWGYVAMQFAQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCIF
  
Inhibitor
Name:
BDBM50040854
Synonyms:
11-(2,6-Diisopropyl-phenylcarbamoyl)-2-methyl-6,11-dihydro-dibenzo[b,e]oxepine-4-carboxylic acid methyl ester | CHEMBL167205
Type:
Small organic molecule
Emp. Form.:
C30H33NO4
Mol. Mass.:
471.5873
SMILES:
COC(=O)c1cc(C)cc2C(C(=O)Nc3c(cccc3C(C)C)C(C)C)c3ccccc3COc12
Structure:
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