Reaction Details Report a problem with these data
Target
Acyl-CoA:cholesterol acyltransferase
Ligand
BDBM50040828
Substrate
n/a
Meas. Tech.
ChEMBL_28192 (CHEMBL637685)
IC50
35±n/a nM
Citation
 Kumazawa, T; Yanase, M; Harakawa, H; Obase, H; Shirakura, S; Ohishi, E; Oda, S; Kubo, K; Yamada, K Inhibitors of acyl-CoA:cholesterol acyltransferase. 1. Synthesis and hypocholesterolemic activity of dibenz[b,e]oxepin-11-carboxanilides. J Med Chem 37:804-10 (1994) [PubMed]  Article 
Target
Name:
Acyl-CoA:cholesterol acyltransferase
Synonyms:
ACAT
Type:
n/a
Mol. Mass.:
35405.31
Organism:
Oryctolagus cuniculus
Description:
n/a
Residue:
305
Sequence:
PLFLKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSILKEMKNNHRAKDLRAPPEQGKIFVARRSLLDELFEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFNLLSYAFGKLPTVVWTWWTMFLSTLSIPYFLFQHWANGYSKSSHPLMYSLFHGLLFMVFQLGILGFGPTYIVLAYTLPPASRFIVILEQIRLIMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYFLFAPTLIYRDSYPRTPTVRWGYVAMQFAQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCIF
  
Inhibitor
Name:
BDBM50040828
Synonyms:
2-Iodo-6,11-dihydro-dibenzo[b,e]oxepine-11-carboxylic acid (2,6-diisopropyl-phenyl)-amide | CHEMBL166647
Type:
Small organic molecule
Emp. Form.:
C27H28INO2
Mol. Mass.:
525.4212
SMILES:
CC(C)c1cccc(C(C)C)c1NC(=O)C1c2ccccc2COc2ccc(I)cc12
Structure:
Search PDB for entries with ligand similarity: