Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50006981
Substrate
n/a
Meas. Tech.
ChEMBL_200976 (CHEMBL802063)
Ki
8.8±n/a nM
Citation
 Glennon, RA; Ablordeppey, SY; Ismaiel, AM; el-Ashmawy, MB; Fischer, JB; Howie, KB Structural features important for sigma 1 receptor binding. J Med Chem 37:1214-9 (1994) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50006981
Synonyms:
CHEMBL19841 | [1-Methyl-2-(3-trifluoromethyl-phenyl)-ethyl]-(3-phenyl-propyl)-amine
Type:
Small organic molecule
Emp. Form.:
C19H22F3N
Mol. Mass.:
321.3799
SMILES:
CC(Cc1cccc(c1)C(F)(F)F)NCCCc1ccccc1
Structure:
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