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Target
Carbonic anhydrase 12
Ligand
BDBM50494688
Substrate
n/a
Meas. Tech.
ChEMBL_1279534 (CHEMBL3097253)
Ki
5.4±n/a nM
Citation
 Carroux, CJ; Rankin, GM; Moeker, J; Bornaghi, LF; Katneni, K; Morizzi, J; Charman, SA; Vullo, D; Supuran, CT; Poulsen, SA A prodrug approach toward cancer-related carbonic anhydrase inhibition. J Med Chem 56:9623-34 (2013) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 12
Synonyms:
CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3
Type:
Enzyme
Mol. Mass.:
39456.00
Organism:
Homo sapiens (Human)
Description:
Catalytic domain of human cloned isozyme was used in the assay
Residue:
354
Sequence:
MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGLSLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
  
Inhibitor
Name:
BDBM50494688
Synonyms:
CHEMBL3092819
Type:
Small organic molecule
Emp. Form.:
C26H34N4O11S
Mol. Mass.:
610.633
SMILES:
CCC(=O)OC[C@H]1O[C@H]([C@H](OC(=O)CC)[C@@H](OC(=O)CC)[C@H]1OC(=O)CC)n1cc(nn1)-c1ccc(cc1)S(N)(=O)=O |r|
Structure:
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