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Target
Delta-type opioid receptor
Ligand
BDBM50494878
Substrate
n/a
Meas. Tech.
ChEMBL_1280724 (CHEMBL3097533)
EC50
1.6±n/a nM
Citation
 Nemoto, T; Ida, Y; Iihara, Y; Nakajima, R; Hirayama, S; Iwai, T; Fujii, H; Nagase, H The most effective influence of 17-(3-ethoxypropyl) substituent on the binding affinity and the agonistic activity in KNT-127 derivatives, ? opioid receptor agonists. Bioorg Med Chem 21:7628-47 (2013) [PubMed]  Article 
Target
Name:
Delta-type opioid receptor
Synonyms:
D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40382.98
Organism:
Homo sapiens (Human)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor.
Residue:
372
Sequence:
MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTACTPSDGPGGGAAA
  
Inhibitor
Name:
BDBM50494878
Synonyms:
CHEMBL4296732
Type:
Small organic molecule
Emp. Form.:
C26H30Cl2N2O3
Mol. Mass.:
489.434
SMILES:
Cl.Cl.[H][C@]12Cc3ccc(O)cc3[C@@]3(CCN1C[C@H](C)O)Cc1nc4ccccc4cc1C[C@@]23O |r,TLB:6:5:32:15.14.13,THB:10:11:32:15.14.13|
Structure:
Search PDB for entries with ligand similarity: