Reaction Details Report a problem with these data
Target
Carbonic anhydrase 7
Ligand
BDBM25899
Substrate
n/a
Meas. Tech.
ChEMBL_1281628 (CHEMBL3102438)
Ki
2.1±n/a nM
Citation
 De Luca, L; Ferro, S; Damiano, FM; Supuran, CT; Vullo, D; Chimirri, A; Gitto, R Structure-based screening for the discovery of new carbonic anhydrase VII inhibitors. Eur J Med Chem 71:105-11 (2014) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 7
Synonyms:
CA-VII | CA7 | CAH7_HUMAN | Carbonate dehydratase VII | Carbonic anhydrase | Carbonic anhydrase VII | Carbonic anhydrase VII (CA VII)
Type:
Enzyme
Mol. Mass.:
29664.11
Organism:
Homo sapiens (Human)
Description:
Human cloned isozyme.
Residue:
264
Sequence:
MTGHHGWGYGQDDGPSHWHKLYPIAQGDRQSPINIISSQAVYSPSLQPLELSYEACMSLSITNNGHSVQVDFNDSDDRTVVTGGPLEGPYRLKQFHFHWGKKHDVGSEHTVDGKSFPSELHLVHWNAKKYSTFGEAASAPDGLAVVGVFLETGDEHPSMNRLTDALYMVRFKGTKAQFSCFNPKCLLPASRHYWTYPGSLTTPPLSESVTWIVLREPICISERQMGKFRSLLFTSEDDERIHMVNNFRPPQPLKGRVVKASFRA
  
Inhibitor
Name:
BDBM25899
Synonyms:
7-chloro-2-methyl-3-(2-methylphenyl)-4-oxo-1,2,3,4-tetrahydroquinazoline-6-sulfonamide | Diulo | Metolazone | Microx | Zaroxolyn
Type:
Small organic molecule
Emp. Form.:
C16H16ClN3O3S
Mol. Mass.:
365.835
SMILES:
CC1Nc2cc(Cl)c(cc2C(=O)N1c1ccccc1C)S(N)(=O)=O
Structure:
Search PDB for entries with ligand similarity: