Reaction Details Report a problem with these data
Target
5-lipoxygenase
Ligand
BDBM50041810
Substrate
n/a
Meas. Tech.
ChEMBL_3982 (CHEMBL619255)
IC50
>30000±n/a nM
Citation
 Müller, K; Leukel, P; Ziereis, K; Gawlik, I Antipsoriatic anthrones with modulated redox properties. 2. Novel derivatives of chrysarobin and isochrysarobin--antiproliferative activity and 5-lipoxygenase inhibition. J Med Chem 37:1660-9 (1994) [PubMed]  Article 
Target
Name:
5-lipoxygenase
Synonyms:
Arachidonate 5-lipoxygenase
Type:
PROTEIN
Mol. Mass.:
49994.23
Organism:
Bos taurus
Description:
ChEMBL_157766
Residue:
430
Sequence:
MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGDIQLIKIEKRKYWFHDDWYLKYITVKTPCGDYIEFPCYRWISGEGEIVLRDGQAKLACDDQIHVLKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWSDFADFEKIFVRISNTISERVMNHWQEDRMFGYQFLNGCNPVMIQRCLKLPDNLPVTTEMVECSLERQLTLEQEIEQGNIFIVDFKLLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQVPGEENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICEYGLFDKANATGG
  
Inhibitor
Name:
BDBM50041810
Synonyms:
1,8-Dihydroxy-2-(4-methoxy-benzyl)-10H-anthracen-9-one | CHEMBL46448
Type:
Small organic molecule
Emp. Form.:
C22H18O4
Mol. Mass.:
346.3759
SMILES:
COc1ccc(Cc2ccc3Cc4cccc(O)c4C(=O)c3c2O)cc1
Structure:
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