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Target
Interleukin-6 receptor subunit alpha
Ligand
BDBM50231569
Substrate
n/a
Meas. Tech.
ChEMBL_218510 (CHEMBL824133)
Ki
>10000±n/a nM
Citation
 van Wijngaarden, I; Hamminga, D; van Hes, R; Standaar, PJ; Tipker, J; Tulp, MT; Mol, F; Olivier, B; de Jonge, A Development of high-affinity 5-HT3 receptor antagonists. Structure-affinity relationships of novel 1,7-annelated indole derivatives. J Med Chem 36:3693-9 (1994) [PubMed]  Article 
Target
Name:
Interleukin-6 receptor subunit alpha
Synonyms:
IL6RA_RAT | Il6r | Il6ra | Interleukin-6 receptor alpha chain
Type:
PROTEIN
Mol. Mass.:
50182.76
Organism:
Rattus norvegicus
Description:
ChEMBL_218510
Residue:
460
Sequence:
MLAVGCTLLVALLAAPAVALVLGSCRALEVANGTVTSLPGATVTLICPGKEAAGNATIHWVYSGSQSREWTTTGNTLVLRAVQVNDTGHYLCFLDDHLVGTVPLLVDVPPEEPKLSCFRKNPLVNAFCEWHPSSTPSPTTKAVMFAKKINTTNGKSDFQVPCQYSQQLKSFSCEVEILEGDKVYHIVSLCVANSVGSRSSHNVVFQSLKMVQPDPPANLVVSAIPGPRWLKVSWQDPESWDPSYYLLQFELRYRPVWSKFTVWPLQVAQHQCVIHDALRGVKHVVQVRGKEEFDIGQWSKWSPEVTGTPWLAEPRTTPAGIPGNPTQVSVEDYDNHEDQYGSSTEATSVLAPVQGSSPIPLPTFLVAGGSLAFGLLLCVFIILRLKKKWKSQAEKESKTTSPPPYPLGPLKPTFLLVPLLTPSGSHNSSGTDNTGSHSCLGVRDPQCPNDNSNRDYLFPR
  
Inhibitor
Name:
BDBM50231569
Synonyms:
Cilansetron | KC-9946
Type:
Small organic molecule
Emp. Form.:
C20H21N3O
Mol. Mass.:
319.4002
SMILES:
Cc1nccn1C[C@H]1CCc2c(C1=O)c1cccc3CCCn2c13
Structure:
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