Reaction Details Report a problem with these data
Target
Cannabinoid receptor 2
Ligand
BDBM50495627
Substrate
n/a
Meas. Tech.
ChEMBL_1291676 (CHEMBL3119423)
Ki
53±n/a nM
Citation
 Lucchesi, V; Parkkari, T; Savinainen, JR; Malfitano, AM; Allarà, M; Bertini, S; Castelli, F; Del Carlo, S; Laezza, C; Ligresti, A; Saccomanni, G; Bifulco, M; Di Marzo, V; Macchia, M; Manera, C 1,2-Dihydro-2-oxopyridine-3-carboxamides: the C-5 substituent is responsible for functionality switch at CB2 cannabinoid receptor. Eur J Med Chem 74:524-32 (2014) [PubMed]  Article 
Target
Name:
Cannabinoid receptor 2
Synonyms:
CANNABINOID CB2 | CB-2 | CB2 | CB2A | CB2B | CNR2 | CNR2_HUMAN | CX5 | Cannabinoid CB2 receptor | Cannabinoid receptor 2 (CB2) | Cannabinoid receptor 2 (CB2R) | hCB2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
39690.94
Organism:
Homo sapiens (Human)
Description:
P34972
Residue:
360
Sequence:
MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCSELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC
  
Inhibitor
Name:
BDBM50495627
Synonyms:
CHEMBL3114173
Type:
Small organic molecule
Emp. Form.:
C20H24N2O2
Mol. Mass.:
324.4168
SMILES:
CC1CCC(CC1)NC(=O)c1cccn(Cc2ccccc2)c1=O |(3.98,-37.64,;5.52,-37.64,;6.29,-38.97,;7.83,-38.97,;8.6,-37.64,;7.83,-36.31,;6.29,-36.31,;10.15,-37.64,;10.91,-36.31,;10.15,-34.97,;12.46,-36.31,;13.23,-34.97,;14.77,-34.97,;15.54,-36.31,;14.77,-37.64,;15.54,-38.97,;17.09,-38.97,;17.86,-37.64,;19.4,-37.64,;20.17,-38.97,;19.4,-40.31,;17.86,-40.31,;13.23,-37.64,;12.46,-38.97,)|
Structure:
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